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The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects

While clinical monitoring of serum vitamin B 12 levels in patients on metformin is inconsistently done, this finding highlights the potential clinical utility of targeted monitoring for certain subsets of individuals, including those genetically at high risk

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To evaluate the significance of this correlation, a two-tailed t- test was performed using OriginPro software

The medical director must get involved

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